Nitrous oxide and decreasing sperm count

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Several data suggest a relevant role in sperm cell pathophysiology, but any conclusive data on its role in spermatozoa motility are still lacking. In the present study, we have correlated NO concentration in semen and kinetic features of sperm cells from normozoospermic fertile donors and infertile patients affected by idiopathic asthenozoospermia. Normozoospermic fertile men exhibited NO concentrations that were significantly lower than those of asthenozoospermic infertile men. A significant linear negative correlation was evident between NO concentration and percentage of total sperm motility.
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Nitric Oxide: Key Features in Spermatozoa

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Role of nitric oxide concentrations on human sperm motility

Several in vitro studies have pointed to the importance of nitric oxide NO in the female and male reproductive system in mammals. Its functions vary from preventing oocyte aging, improving the integrity of the microtubular spindle apparatus in aged oocytes, modulating the contraction of the oviduct, to regulating sperm physiology by affecting the motility, inducing chemotaxis in spermatozoa, regulating tyrosine phosphorylation, enhancing the sperm-zona pellucida binding ability, and modulating the acrosomal reaction. In spermatozoa, NO exerts its functions in different ways, which involve key elements such as the soluble isoform of guanylate cyclase, cyclic guanosine monophosphate cGMP , cyclic adenosine monophosphate cAMP , protein kinase A PKA , adenylate cyclase, and the extracellular signal-regulated kinase ERK pathway. Furthermore, NO leads to the S-nitrosylation of several sperm proteins, among them a substantial group associated with energy generation and cell movement, but also with signal transduction, suggesting a role for S-nitrosylation in sperm motility and in modulating the sperm function, respectively.
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Role of nitric oxide concentrations on human sperm motility

Iranian scientists have linked a chemical that plays an essential role in many bodily functions to sperm DNA damage and male infertility, the 22nd annual conference of the European Society of Human Reproduction heard today Monday. Dr Iraj Amiri, embryology laboratory director at the IVF Centre, Fatemieh Hospital, Hamadan, Iran, said: "In recent years nitric oxide NO has been recognised as a molecule that plays an important role in regulating the biology and physiology of the reproductive system, and we know that it can affect human sperm functions, such as motility, viability and metabolism. At low concentrations it can have a positive effect on cells, but a negative effect at high concentrations. High concentrations of NO were significantly correlated with greater sperm DNA damage, and low concentrations of NO were significantly correlated with better sperm motility. The researchers collected semen samples from 45 infertile patients and 70 healthy sperm donors.
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Endogenous nitric oxide NO is an important functional mediator in several physiological systems, including the reproductive system. However, when generated in excessive amounts for long periods, mainly during immunological reactions, NO is cytotoxic and cytostatic for invading microbes, as well as for the cells generating it and the tissues present around it. Since infertility associated with urogenital tract infection in males and females is also accompanied by reduced sperm motility and viability, it is possible that reduced fertility in these patients is due to NO-induced sperm toxicity. Furthermore, we tested whether inhibition of NO synthesis prevents sperm motility and viability by incubating washed total cells present in the semen spermatozoa, round cells with N-nitro-L-arginine-methyl-ester L-NAME , a NO synthesis inhibitor. Treatment of purified spermatozoa with SNAP or SNP decreased forward progressive sperm motility and straight line velocity, and also increased the percentage of immotile spermatozoa in a concentration-dependent manner.
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