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Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Herein, we reveal that miRa is significantly downregulated in NSCLC tissues and cell lines, suggesting that miRa might function as a tumor suppressor in lung cancer. We also confirmed that epidermal growth factor receptor EGFR is a direct target of miRa, and our data reveal that siRNA knockdown of EGFR can inhibit cell proliferation, promote apoptosis and arrest cell-cycle progression.
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MicroRNA-34a/EGFR axis plays pivotal roles in lung tumorigenesis

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MicroRNAa/EGFR axis plays pivotal roles in lung tumorigenesis | Oncogenesis

Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Although surgery remains the mainstay of curative treatment for colorectal cancer CRC , many patients still have high chance to experience disease relapse.
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Cisplatin-induced epigenetic activation of miR-34a sensitizes bladder cancer cells to chemotherapy

Studies have demonstrated that miRa, which is a direct target of the p53 tumor suppressor gene, functions as a tumor suppressor and is associated with the tumor growth and metastasis of various human malignances. However, the role of miRa in osteosarcoma has not been totally elucidated. In the present study, the effects of miRa on osteosarcoma and the possible mechanism by which miRa affected the tumor growth and metastasis of osteosarcoma were investigated. Over-expression of miRa partially inhibited proliferation, migration and invasion of osteosarcoma cells in vitro, as well as the tumor growth and pulmonary metastasis of osteosarcoma cells in vivo.
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Try out PMC Labs and tell us what you think. Learn More. MicroRNAa miRa has been shown to be a master regulator of tumor suppression in many types of cancers including breast cancer. Overexpression of miRa by lentivirus suppresses cell proliferation, S phase ratio, and tumor formation in an E2-dependent manner in vitro.
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